| TOX 201 | Poisons, People and the Environment | UNITS: 3 - Offered in Spring Only, Natural Sciences |
| Introduction to the fascinating world of chemical poisons including their many and varied effects on people as well as the environment. Learn how and why poisons have played an important role in history, how to critically evaluate the chemical risk information reported in the media, and the underlying principles of "the basic science of poisons." |
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| TOX 401 | Principles of Toxicology | UNITS: 4 - Offered in Fall Only |
| Prerequisite: CH 220 or CH 221; BIO 181 or ZO 160 |
| Introduce students to the basic principles of toxicology. Will cover the history and scope of the field; absorption, distribution, metabolism and elimination of toxicants; types and mechanisms of toxic action; carcinogenesis; environmental toxicology as well as human and ecological risk assessment. |
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| TOX 415 | Environmental Toxicology and Chemistry | UNITS: 4 - Offered in Spring Only |
| Prerequisite: CH 220 or CH 221; BIO 181 or ZO 160 recommended |
| Environmental toxicology and chemistry including the sources, fate, and effects of chemicals in the environment. Emphasis on contemporary problems in human health and the environment. |
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| TOX 490 | Seminar in Environmental Toxicology | UNITS: 1 - Offered in Spring Only |
| Prerequisite: TOX 401 |
| Presentation of research findings by invited scientist; presentation of literature research by students; guidelines for presenting oral and poster presentations at scientific meetings. |
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| TOX 495 | Special Topics in Toxicology | UNITS: 1-3 - Offered in Fall Spring Summer |
| Offered as needed to present materials unavailable in regular course offerings or for offering new courses on a trial basis. |
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| TOX 499 | Undergraduate Research in Toxicology | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: Sophomore standing or higher |
| Research for students in Toxicology. In lieu of a syllabus, student and professor will prepare a contract which details the research and how the results will be disseminated. |
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| TOX 501 | Principles of Toxicology | UNITS: 4 - Offered in Spring Only |
| Prerequisite: (CH 220 or CH 221) and (BIO 181 or ZO 160) |
| Introduction to basic principles of toxicology, including the history and scope of the field; absorption, distribution, metabolism and elimination of toxicants; types and mechanisms of toxic action; carcinogenesis; environmental toxicology as well as human and ecological risk assessment. Students cannot obtain credit for both TOX 401 and TOX 501. |
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| TOX 515 | Environmental Toxicology | UNITS: 4 |
| Prerequisite: Two years of biology |
| Evaluation of the nature, distribution and significance of microchemical contamination. Emphasis on current, relevant problems. |
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| TOX 595 | Special Topics | UNITS: 1-3 |
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| TOX 601 | Toxicology Seminar | UNITS: 1 - Offered in Fall and Spring |
| Prerequisite: Graduate standing |
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| TOX 620 | Special Problems | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: Graduate standing |
| Topics include responsibility in science, environmental fate of chemicals, developmental toxicology, lab rotations, journal club and wildlife toxicology. |
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| TOX 628 | Principles of Reproductive and Developmental Toxicology Research | UNITS: 1 - Offered in Fall Only |
| Prerequisite: BCH 451 |
| Review of male and female mammalian reprodcutive physiology and embryology. In vivo and in vitro research approaches involving gene-based, protein, and cellular methods to study abnormal reproduction and development. |
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| TOX 660 | Free Radicals In Toxicology | UNITS: 1 - Offered in Fall Only, Offered Alternate Years |
| Prerequisite: BCH 451 and TOX 710 |
| Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms. |
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| TOX 688 | Non-Thesis Masters Continuous Registration - Half Time Registration | UNITS: 1 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain half-time continuous registration to complete incomplete grades, projects, final master's exam, etc. |
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| TOX 689 | Non-Thesis Master Continuous Registration - Full Time Registration | UNITS: 3 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain full-time continuous registration to complete incomplete grades, projects, final master's exam, etc. Students may register for this course a maximum of one semester. |
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| TOX 690 | Master's Exam | UNITS: 1-6 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non thesis master's programs who have completed all other requirements of the degree except preparing for and taking the final master's exam. |
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| TOX 693 | Master's Supervised Research | UNITS: 1-9 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| Instruction in research and research under the mentorship of a member of the Graduate Faculty. |
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| TOX 695 | Master's Thesis Research | UNITS: 1-9 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| Thesis research. |
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| TOX 696 | Summer Thesis Research | UNITS: 1 - Offered in Summer |
| Prerequisite: Master's student |
| For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research. |
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| TOX 699 | Master's Thesis Preparation | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their theses. |
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| TOX 701 | Fundamentals of Toxicology | UNITS: 3 - Offered in Fall Only |
| Prerequisite: BCH 451, Senior standing or Graduate standing |
| The basis of toxic action at cellular and molecular levels covering the absorption, distribution, elimination and metabolism of toxicants; toxic action (acute toxicity, carcinogenesis, mutagenesis, organ toxicity, etc.); chemical classes of toxicants; and toxicity testing. |
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| TOX 704 | Chemical Risk Assessment | UNITS: 1 |
| Prerequisite: TOX 701, a ST course |
| Concepts and vocabulary of risk assessment. Risk assessment models and techniques used in cancer and non-cancer risk assessment and strategies for successful risk communications. Case studies of risk assessment and issues of current interest. Utilization of background in toxicology and statistics to examine a critical end-point in toxicological science, the quantitative risk assessment. |
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| TOX (IMM) 705 | Immunotoxicology | UNITS: 2 - Offered in Spring Only |
| Prerequisite: TOX 701 |
| Concepts in the study of adverse effects of chemicals on the immune system, including allergic responses, autoimmunity and immunosuppression. Significance of immunotoxic effects resulting from environmental or workplace exposure. Role of immunotoxicity in risk assessment. |
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| TOX 710 | Molecular and Biochemical Toxicology | UNITS: 3 - Offered in Spring Only |
| Prerequisite: BCH 451; TOX 701 |
| Fundamental understanding of biochemical, molecular and cellular mechanisms through which xenobiotics alter cellular homeostasis, produce toxicity and alter organ function. Current biochemical, molecular and cellular experimental approaches for study of biochemical mechanisms of toxicity. |
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| TOX 715 | Environmental Toxicology | UNITS: 3 - Offered in Fall Only |
| Prerequisite: Two years of biology |
| Evaluation of fundamental processes relating fate and effects of chemicals in the environment. Emphasis on effects of pollutants on non-human species, environmental risk assessment and historically relevant incidents of environmental contaminants. |
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| TOX 721 | Chemical Carciogenesis | UNITS: 1 |
| Prerequisite: BCH 553, TOX 701, TOX 710 |
| Emphasis on mechanisms including somatic mutation hypothesis, pathology of neoplasia, multistage carcinogenesis, tumor promotion, oncogenes, tumor suppressor genes and rodent bioassays. Fundamentals of cancer biology and their relationships to chemical-induced carcinogenesis. |
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| TOX (ENT) 722 | Insecticide Toxicology | UNITS: 3 |
| Prerequisite: BCH 451, CH 223 |
| Chemistry, biochemistry and toxicology of major classes of insecticide chemicals including relationships between chemical structure and toxicity; mode of action of insecticides; metabolism of insecticides in insects, mammals and environment; insecticide selectivity and resistance mechanisms; nontarget and environmental effects from insecticide use; registration and regulation of insecticides; and risk assessment associated with insecticide use. |
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| TOX (CS) (HS) (SSC) 725 | Pesticide Chemistry | UNITS: 1 - Offered in Spring Only |
| Prerequisite: CH 201 and 221 |
| Chemical properties of pesticides including hydration and solvation, ionization, volatilization, lipophilicity, molecular structure and size, and reactivity and classification according to chemical description, mode of action or ionizability. Taughtduring the first 5 weeks of semester. Drop date is last day of 3rd week of the minicourse. |
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| TOX (CS) (HS) (SSC) 727 | Pesticide Behavior and Fate In the Environment | UNITS: 2 - Offered in Spring Only |
| Prerequisite: CS(HS,SSC,TOX) 725, SSC 200 |
| Sorption/desorption, soil reactivity, movement, volatilization, bioavailability, degradation and stability of pesticides in the environment. Taught during the last 10 weeks of semester. Drop date is last day of 3rd week of the minicourse. |
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| TOX (CBS) 771 | Cancer Biology | UNITS: 4 - Offered in Fall Only |
| Prerequisite: CBS 770 |
| A comprehensive graduate course focusing on the molecular and cellular bases of cancer. Targets of oncogenic mutations will be discussed as well as their impact on cell proliferation, cell survival, and the invasion of normal tissues by tumorigeniccells. State-of-the-art technologies to detect oncogenic mutations and characterize transformed cells will be discussed as well as therapeutic strategies for the rational treatment of cancer. |
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| TOX 795 | Special Topics in Toxicology | UNITS: 1-3 - Offered in Fall and Spring |
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| TOX 801 | Toxicology Seminar | UNITS: 1 - Offered in Fall and Spring |
| Prerequisite: Graduate standing |
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| TOX 820 | Special Problems In Toxicology | UNITS: 1-3 - Offered in Fall and Spring |
| Prerequisite: Graduate standing |
| Topics include responsibility in science, environmental fate of chemicals, developmental toxicology, lab rotations, Journal Club, and wildlife toxicology. |
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| TOX 860 | Free Radicals in Toxicology | UNITS: 1 - Offered in Fall Only, Offered Alternate Years |
| Prerequisite: BCH 451 and TOX 710 |
| Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms. |
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| TOX 890 | Doctoral Preliminary Examination | UNITS: 1-9 - Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| For students who are preparing for and taking written and/or oral preliminary exams. |
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| TOX 893 | Doctoral Supervised Research | UNITS: 1-9 - Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| Instruction in research and research under the mentorship of a member of the Graduate Faculty. |
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| TOX 895 | Doctoral Dissertation Research | UNITS: 1-9 - Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| Dissertation research. |
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| TOX 896 | Summer Dissertation Research | UNITS: 1 - Offered in Summer |
| Prerequisite: Doctoral student |
| For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research. |
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| TOX 899 | Doctoral Dissertation Preparation | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| For students who have completed all credit hour, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations. |
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