GENETICS - GN

GN 301Genetics in Human Affairs3(3-0-0) F,S,Sum
Appreciation and understanding of genetics in everyday life. Genetic perspective on normal human development, birth defects, birth control, cancer, organ transplants, intelligence, mental illness, and radiation and chemical exposure and issues raised by applications of recently developed genetic techniques such as in vitro fertilization, genetic engineering and prenatal monitoring.
Course Offerings: fall sprg


GN 311Principles of Genetics4(3-0-1) F,S,Sum
Preq: BIO 183 or ZO 160
Basic concepts and principles of prokaryotic and eukaryotic genetics. Mendelian inheritance, polygenic inheritance, linkage and mapping, chromosome aberrations, population genetics, evolution, DNA structure and replication, gene expression, mutation, gene regulation, extranuclear inheritance, bacterial and viral genetics, and recombinant DNA technology. Sophomore standing or permission of the instructor.
Course Offerings: fall


GN 412Elementary Genetics Laboratory1(0-3-0) F,S
Coreq: GN 411
Genetic experiments and demonstrations using a variety of bacterial, plant and animal organisms. Mendelian inheritance, linkage analysis, population genetics, cytogenetics, biochemical genetics, DNA isolation, electrophoresis, and Southern blotting.
Course Offerings: fall sprg WolfWare Info


GN 413Advanced Genetics3(3-0-0) F,S
Preq: GN 411
Biological macromolecules and their interactions. Chromatin and chromosome structure. Bacteria, viruses, plants, animals and fungi as genetic systems. Transcription, RNA processing, genetic code, translation, DNA replication and the cell cycle. RFLP mapping. DNA and forensics. Molecular genetics of disease. Genetic transformation and cloning of plants and animals. Recombinant DNA methodology. Students cannot receive credit for both GN 413 and GN 513
Course Offerings: fall WolfWare Info


GN 414Genes and Development3(3-0-0) S
Preq: GN 411
Genes and genetic pathways that control development in animals; overview of early, pivotal experiments in embryology and genetics; use of molecular biology, genomics and bioinformatics to study genes and development; concentration on four model systems; presentation and discussion of major issues in developmental biology.
Course Offerings: fall sprg WolfWare Info


GN 415Genome Science3(3-0-0) S
Preq: GN 411
Complementation of modern genomics approaches with classical and molecular genetics; goals of major genome projects in animals, plants, humans, and microorganisms; genomic science opportunities at NCSU and in the Research Triangle; presentation and discussion of current literature; and preparation for careers in genomics-related fields.
Course Offerings: sprg


GN 492External Learning Experience1-6 F,S
Preq: Sophomore standing
A learning experience in agriculture and life sciences within an academic framework that utilizes facilities and resources which are external to the campus. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and the academic dean prior to the experience.
Course Offerings: fall sum1 sum2 sprg


GN 493Special Problems in Genetics1-6 F,S
Preq: Sophomore standing
A learning experience in agriculture and life sciences within an academic framework that utilizes campus facilities and resources. Arrangements must be initiated by student and approved by a faculty adviser and the departmental teaching coordinator.
Course Offerings: fall sum1 sum2 sprg


GN 495Special Topics in Genetics1-3 F,S,Sum
Offered as needed to present materials not normally available in regular course offerings or for offering of new courses on a trial basis.
Course Offerings: fall


GN 504Human Genetics3(3-0-0) F
Preq: GN 301 or 411
Basic principles needed for an understanding of genetics of man. Current knowledge and important areas of research in human genetics.


GN 513Advanced Genetics3(3-0-0) F,S
Preq: GN 411
Biological macromolescules and their interactions. Chromatin and chromosome structure. Bacteria, viruses, plants, animals and fungi as genetic systems. Transcription, RNA processing, genetic code, translation, DNA replication and cell cycle. RFLP mapping. DNA and forensics. Genetic transformation and cloning of plants and animals. Recombinant DNA methodology. Credit for both GN 413 and GN 513 is not allowed.
Course Offerings: fall


GN (ENT) 527Insect Neurogenomics3(3-0-0) S (ALTYREVEN)
Preq: GN 413/513
Sensory processing systems in the insect brain (visual, olfactory, gustatory, and mechanosensory), learning and memory and circadian rhythm. Each process will be considered at the behavioral, anatomical, neural, and genetic level. Examples will bedrawn from multiple insect species, using recent studies. Techniques: quantitative real-time PCR, microarrays, mapping quantitative trait loci, Drosophila transgenics, RNAi, imaging neuronal activity, etc. For Graduate students with background in molecular biology techniques.


GN 685Master's Supervised Teaching1-3 F,S
Preq: Master's student
Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.
Course Offerings: fall sprg


GN 688Non-Thesis Masters Continuous Registration - Half Time Registration1(1-0-0) F,S,Sum
Preq: Master's student
For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain half-time continuous registration to complete incomplete grades, projects, final master's exam, etc.
Course Offerings: fall sprg


GN 689Non-Thesis Master Continuous Registration - Full Time Registration3(3-0-0) F,S,Sum
Preq: Master's student
For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain full-time continuous registration to complete incomplete grades, projects, final master's exam, etc. Students may register for this course a maximum of one semester.
Course Offerings: fall sprg


GN 690Master's Examination1-6 F,S
Preq: Master's student
For students in non-thesis master's programs who have completed all other requirements of the degree except preparing for and taking the final master's exam.
Course Offerings: fall sprg


GN 693Master's Supervised Research1-9 F,S
Preq: Master's Student
Instruction in research and research under the mentorship of a member of the Graduate Faculty.
Course Offerings: fall sprg


GN 695Master's Thesis Research1-9 F,S
Preq: Master's Student
Thesis Research
Course Offerings: fall sprg


GN 696Summer Thesis Research1(1-0-0) Sum
Preq: Master's student
For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.
Course Offerings: sum1


GN 699Master's Thesis Preparation1-3 F,S
Preq: Master's Student
For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their thesis.
Course Offerings: fall sum1 sum2 sprg


GN 701Molecular Genetics3(3-0-0) F
Preq: GN 411
A discussion of the structure and function of genetic material at a molecular level. Consideration of both prokaryotic and eukaryotic systems. The aim to describe genetics in terms of chemical principles.
Course Offerings: fall WolfWare Info


GN 702Cellular and Developmental Genetics3(3-0-0) S
Preq: GN 701
Regulation of genes involved in cellular function, differentiation and development in eukaryotes. Presentation of biological systems and model organisms used to study genetic control of cellular and developmental processes.
Course Offerings: sprg


GN 703Population and Quantitative Genetics3(3-0-0) S
Preq: GN 411, ST 512
Mutation and origin of genetic variation. Measuring genetic variation in natural populations. Gene and genotype frequencies. Hardy-Weinberg equilibrium. Values, means, genetic and environmental variance, heritability of quantitative traits. Random genetic drift and inbreeding. Natural and artifical selection. Theory and tests of models of maintenance of genetic variation. Molecular evolution of genes and proteins. Genome evolution.
Course Offerings: sprg WolfWare Info


GN (ANS) 708Genetics of Animal Improvement3(3-0-0) S
Preq: GN 411, ST 512
Emphasis on the utilization of basic principles of population and quantitative genetics in animal improvement. Factors affecting genic and genotypic frequencies and methods of estimating genetic and nongenetic variance, heritabilities and breeding values. The roles of mating systems and selection procedures in producing superior genetic populations.
Course Offerings: fall


GN (ANS) 713Quantitative Genetics and Breeding3(3-0-0) F
Quantitative and population genetic theory of breeding problems; partitioning of genetic variance, maternal effects, genotype by environment interaction and genetic correlation; selection indexes; design and analysis of selection experiments; marker-assisted selection.
Course Offerings: fall


GN (CS) 719Origin and Evolution Of Cultivated Plants1(1-1-0)
Preq: CS(GN,HS)741; GN 511
Review of concepts of speciation and classification; origin and variation in plants; theories related to agricultural origins; variation patterns of cultivated species; evolution under domestication; utilization of wild and unadapted germplasm in plant breeding.


GN (CS) (HS) 720Molecular Biology In Plant Breeding3(0-3-0) S. (Alt. yrs.)
Preq: CS(GN,HS) 741, GN 701
Theory and principles of molecular biology applied to plant breeding. Experimental approaches to induce genetic change, cytoplasmic recombination, haploid utilization and potentials of molecular techniques for solving breeding problems.
Course Offerings: sprg


GN (ST) 721Genetic Data Analysis3(3-0-0) S. (Alt. yrs.)
Preq: ST 430 and GN 411
Analysis of discrete data, illustrated with genetic data on morphological characters allozymes, restriction fragment length polymorphisms and DNA sequences. Maximum likelihood estimation, including iterative procedures. Numerical resampling. Development of statistical techniques for characterizing genetic disequilibrium and diversity. Measures of population structure and genetic distance. Construction of phylogenetic trees. Finding alignments and similarities between DNA sequences. Locating genes with markers.
Course Offerings: sprg


GN (FOR) 725Forest Genetics3(3-0-0) S
Preq: GN 411
Application of genetic principles to silviculture, management and wood utilization. Emphasis on variation in wild populations, the bases for selection of desirable qualities and fundamentals of controlled breeding.
Course Offerings: sprg


GN (FOR) 726Advanced Topics In Quantitative Genetics3(3-0-0) F. (Alt. yrs.)
Preq: GN(FOR) 725, GN(ST) 770 or GN(ANS) 713
Advanced topics in statistics and population genetics pertinent to current research problems in genetics with special applications to forestry. Basic statistical and genetic theory reviewed as bases for intensive study of selection theory and experimental and mating design evaluation. Study of genetics of natural populations for evolutionary interest as well as for their implications to breeding theory.


GN (MB) (PB) (PP) 730Fungal Genetics and Physiology3(2-3-0) S. (Alt. yrs.)
Preq: BCH 451, BO 775, GN 411 or PP 501
Basic concepts of genetics and physiology of fungi, with emphasis on saprophytic and plant pathogenic mycelial fungi. Current literature on evolution, cell structure, growth and development, gene expression, metabolism, sexual and asexual reproduction and incompatibility systems. Laboratory exercises on mutant isolation, sexual and parasexual analysis, genetic transformation, and RFLP and isozyme analysis.


GN 735Functional Genomics3(3-0-0) F
Preq: GN 411, Graduate standing
Methodology of experimental genomics; genome sequencing, gene expression arrays, genomic screens, proteomics. Aims and achievements of microbial, plant, animal, human genome projects. Applications of genomics including parasitology, breeding, functional genomics, evolutionary genetics. Interface with bioinformatics, data technology.
Course Offerings: sprg WolfWare Info


GN (ZO) 740Evolutionary Genetics3(3-0-0) F, Alt yr(even)
Preq: GN 703
Genetic basis of evolution. Molecular evolution, molecular population genetics, evolutionary genetics of quantitative characters and the genetics of speciation. Critical reading of original research publications and student seminars.
WolfWare Info


GN (CS) (HS) 745Quantitative Genetics In Plant Breeding1(1-0-0) S. (Alt. yrs.)
Preq: CS(GN, HS) 741, ST 512, course in quantitative genetics recommended
Theory and principles of plant quantitative genetics. Experimental approaches of relationships between type and source of genetic variability, concepts of inbreeding, estimations of genetic variance and selection theory.
Course Offerings: sprg


GN (CS) (HS) 746Breeding Methods2(2-0-0) S, Alt yrs
Preq: CS (GN, HS) 741, ST 512
Theory and principles of plant breeding methodology including population improvement, selection procedures, genotypic evaluation, cultivar development and breeding strategies.
Course Offerings: sprg


GN (CS) (HS) (PP) 748Breeding For Pest Resistance2(2-0-0) F, Alt yrs
Preq: CS(GN, HS) 741, PP 315, ST 512
Theory and principles of breeding for pest resistance. Experimental approaches for examining genetics of host-parasite interactions, expression and stability of pest resistance and breeding strategies for developing pest-resistant cultivars.


GN 750Developmental Genetics3(3-0-0) S. (Alt. yrs.)
Preq: GN 701, GN 702
Action and regulation of genes and gene-products in development and differentiation. Examples from microorganisms, plants and animals. Emphasis on molecular and biochemical aspects of mechanisms controlling gene expression in eukaryotic cell differentiation.


GN 755Population Genetics3(3-0-0) S. (Alt. yrs.)
Preq: GN 703
Theoretical population genetics and its relationship to natural and experimental populations. Single locus and multilocus systems, history of a gene in a population, diffusion approximations, suitability of models to natural and experimental populations.


GN (ST) 756Computational Molecular Evolution3(3-0-0) F (Alt. yrs)
Preq: GN 411 and ST 511
Phylogenetic analyses of nucleotide and protein sequence data. Sequence alignment, phylogeny reconstruction and relevant computer software. Prediction of protein secondary structure, database searching, bioinformatics and related topics. Project required.
WolfWare Info


GN (ST) 757Statistics for Molecular Quantitative Genetics3(3-0-0) F, Alt Yr.(even)
Preq: ST 512 and GN 703 or ST 721
Genetic mapping data. Linkage map reconstruction, quantitative genetical models. Statistical methods and computer programs for mapping quantitative trait loci and estimating genetic architecture of quantitative traits.
Course Offerings: fall


GN (MB) 758Prokaryotic Molecular Genetics3(3-0-0) S
Preq: BCH 451 or GN 411
Structure and function in prokaryotic molecular genetics, with emphasis on mutations and mutagenic pathways, transcriptional and translational regulation, RNA processing, DNA replication and recombination and characterization of recombinant DNA molecules. Applications of genetic and recombinant DNA techniques to microbial processes, including strain construction and enhancement of gene expression.
Course Offerings: sprg WolfWare Info


GN (MB) 760Experimental Microbial Genetics4(2-6-0) S
Preq: GN 411, MB 351
Laboratory-oriented presentation of current methodologies and concepts in molecular microbial genetics and their application to strain construction, plasmid and phage manipulations, mutagenesis, cloning and genetic engineering of microorganisms.


GN (BCH) 761Advanced Molecular Biology Of the Cell3(3-0-0) S, Alt yrs
Preq: BCH 703 and 705
An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions.
Course Offerings: sprg


GN (BCH) 768Nucleic Acids: Structure and Function3(3-0-0) S, Alt yrs
Preq: BCH 701 and 703
An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions.


GN (ST) 770Statistical Concepts In Genetics3(3-0-0) S, Alt yrs
Preq: GN 703
Coreq: ST 512
Migration, mutation, selection, drift, linkage, mating system and other processes bearing on rates of change in population frequencies, means and variances; magnitude and nature of genotypic and nongenotypic variability and their role in alternativeprocedures of plant and animal breeding; experimental and statistical approaches to the analysis of quantitative inheritance.


GN 801Seminar1(1-0-0) F,S
Preq: Graduate standing
Informal group discussion of prepared topics assigned by instructor.
Course Offerings: fall sprg


GN 809Colloquium in Genetics2(2-0-0) F,S
Preq: Graduate standing
Informal group discussion of prepared topics assigned by instructor.


GN 810Special Topics in Genetics1-4 F,S
Critical study of selected areas and special topics of current interest in genetics and related fields.
Course Offerings: fall sprg


GN 820Special Problems1-3 F,S
Preq: Advanced Graduate standing
Special topics designed for additional experience and research training.
Course Offerings: fall


GN 850Professionalism and Ethics1(1.5-0-0) F
Preq: Graduate standing
The course is designed to give students background in professionalism, scientific ethics and responsible conduct of science. Topics include the role of the scientist in society, ethical theory, data acquisition and ownership, scientific midconduct,authorship, peer review, conflicts of interest and commitment, intellectual property, ethics of teaching and mentoring, ethical treatment of animal and human subjects, ethics of genetics research, job hunting and interviewing.
Course Offerings: fall WolfWare Info


GN (CS) (HS) 860Plant Breeding Laboratory1(1-0-0) S, Alt yrs
Preq: CS(GN,HS)741
Visitation of plant breeding projects in the Depts. of CS and HS at NC State, along with commercial seed companies. Discussion and viewing of breeding objectives, methods and equipment and teaching and practice of hybridization methods.
Course Offerings: sprg


GN (CS) (HS) 861Plant Breeding Laboratory1(1-0-0) F, Alt yrs
Preq: CS(GN,HS)741
Visitation of plant breeding projects in the Depts. of CS and HS at NC State, along with commercial seed companies. Discussion and viewing of breeding objectives, methods and equipment and teaching and practice of hybridization methods.
Course Offerings: fall


GN 885Doctoral Supervised Teaching1-3 F,S
Preq: Doctoral student
Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.
Course Offerings: fall sprg


GN 890Doctoral Preliminary Examination1-9 F,S
Preq: Doctoral student
For students who are preparing for and taking written and/or oral preliminary exams.
Course Offerings: fall sprg


GN 893Doctoral Supervised Research1-9 F,S
Preq: Doctoral student
Instruction in research and research under the mentorship of a member of the Graduate Faculty.
Course Offerings: fall sprg


GN 895Doctoral Dissertation Research1-9 F,S
Preq: Doctoral student
Dissertation Research
Course Offerings: fall sum1 sprg


GN 896Summer Dissertation Research1(1-0-0) Sum
Preq: Doctoral student
For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.
Course Offerings: sum1


GN 899Doctoral Dissertation Preparation1-3 F,S
Preq: Doctoral student
For students who have completed all credit hour requirements, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.
Course Offerings: fall sum1 sum2 sprg