BME - Biomedical Engineering


BME 201Computer Methods in Biomedical EngineeringUNITS: 3 - Offered in Fall Only
Prerequisite: BME matriculated students
Students develop computer-based problem solving techniques using Excel and MATLAB to solve introductory problems in Biomedical Engineering. Emphasis is on developing solution algorithms, implementing these with spreadsheets and computer programming, and presenting results in a clear and concise manner. Students registered for BME 201 who fail to matriculate into BME will be dropped from the course.


BME (MSE) 203Introduction to the Materials Science of BiomaterialsUNITS: 3 - Offered in Fall and Spring
Prerequisite: C- or better in CH 101, CH 102 and PY 205
This course introduces fundamental physical principles governing the structure, processing, properties and performance of metallic, ceramic and polymeric materials. Relationships are developed defining how mechanical, physical and chemical properties are controlled by microstructure and chemistry. Material failure modes are develped with an emphasis on biocompatibility and the applications/performance of materials in the human body. Basic aspects of material biocompatibility are presented, leading into studies of the current and future applications of biomaterials.


BME 204Biomedical MeasurementsUNITS: 3 - Offered in Fall Only
Prerequisite: BME Majors
This course will introduce students to modern topics in biomedical engineering and areas of emphasis in the biomedical engineering curriculum through the study and use of biomedical measurement tools. The course will include a lecture and a laboratory component.


BME 210Biomedical ElectronicsUNITS: 4 - Offered in Spring Only
Prerequisite: MA 242, PY 208. For BME Majors only.
Fundamentals of analog and digital circuit analysis and design as applied to biomedical instrumentation and measurement of biological potentials. Passive circuit components, node and mesh analysis, transient behavior, operational amplifiers, frequency response, analog filter design, diode, transistors, biological signal acquisition, binary math and logical operators, digital circuit design, circuit simulation tools and techniques. Laboratory exercises supplement the topics presented in class lectures.


BME 252Biomedical Engineering Design and Manufacturing IUNITS: 1 - Offered in Fall and Spring
Prerequisite: BME Majors
Students will learn the basic tools of design such as solid modeling by means of web-based tutorials and a series of small CAD project assignments. Students will learn to use current software for design, analysis, and computer-aided manufacturing (CAM). Students will also be introduced to modern manufacturing through the transition from CAD (Computer-Aided Design) to CAM using modern rapid manufacturing equipment to carry out one small, well-defined design and manufacturing project.


BME 301Human Physiology for Engineers IUNITS: 3 - Offered in Fall Only
Prerequisite: BME 201 and either ZO 160 or BIO 183, BME Majors, Corequisite: BME 311
This course includes a quantitative approach to human physiology from the biomedical engineering perspective with an emphasis on neural, sensory, muscle, and cardiac physiology. Autonomic neural and somatic motor control will be discussed. Engineering applications, including neural stimulators, functional imaging, cochlear implants, artificial noses, vestibular implants, visual implants, artificial larynges, pacemakers and defibrillators will be discussed. Assignments include computer-based exercises using MATLAB.


BME 302Human Physiology for Engineers IIUNITS: 3 - Offered in Spring Only
Prerequisite: BME 301. For BME Majors only.
This course explores a quantitative approach to human physiology from the biomedical engineering perspective with an emphasis on systems physiology described using mechanical properties. Topics include the physiological and mechanical behavior of the blood vessels, lungs, kidney muscles and larynx. In the course lab exercises, students investigate mechanical properties of fluids, electrolyte exchange in dialysis, spirometry and blood pressure measurement among other topics. The course culminates with the design of a novel laboratory experiment.


BME 311Linear Systems in Biomedical EngineeringUNITS: 3 - Offered in Fall Only
Prerequisite: BME 201 and (ECE 331 or BME 210). Corequisite: BME 301 and MA 341. For BME Majors only.
Fundamentals of linear systems analysis as applied to problems in biomedical modeling and instrumentation. Properties of biomedical systems and signals. Representation of continuous- and discrete-time signals and system response. Convolution. Fourier analysis in continuous and discrete domains. Laplace transform. Frequency response and its application in biomedical systems. Filter design. Circuit analogs to mechanical and thermodynamics systems and their applications in modeling biomedical systems. Applications in biomedical instrumentation. Students use MATLAB to simulate and analyze biomedical linear systems. BME majors only.


BME 312Analog and Digital Circuits LaboratoryUNITS: 1 - Offered in Fall Only
Prerequisite: ECE 331, BME Majors
Laboratory in analog and digital circuit analysis. Electrical safety; Exercises in resistor networks, capacitors and inductors, steady-state and dynamic circuit behavior, active circuits, amplifiers, logic gates, combinatorial and sequential circuits, elementary digital system design, A/D conversion, biomedical applications.


BME 342Analytical and Experimental Methods for Biomedical EngineersUNITS: 3 - Offered in Spring Only
Prerequisite: BME 201; MAE 208 or CE 215; MAE 314 or CE 313; MA 341
Experimental and analytic tools are developed and used to solve problems in biomedical engineering. Techniques include kinematic analysis, closed form and finite element analysis of stresses and strains in a body, and failure analysis. Transducersnecessary for experimental analysis and testing are introduced. Students learn advanced software packages such as the finite element program ANSYS and the dynamic analysis program ADAMS to assist in their analyses.


BME 352Biomedical Engineering Design and Manufacturing IIUNITS: 2 - Offered in Spring Only
Prerequisite: BME 252; BME majors
Students will be required to continue their use of the tools learned in Biomedical Design and Manufacturing I in the context of modern design practices and manufacturing processes. The organizational and project management tools of moderm design will be introduced, and a technical discussion of a modern manufacturing technology will be introduced each week.


BME (MSE) 362Biomaterials CharacterizationUNITS: 3 - Offered in Spring Only
Prerequisite: (CH 220 or 221) and (BME 203 or MSE 200 or MSE 201)
Introductory laboratory experience focused on integrating engineering and biological principles by exploring key topics in biomaterials. Topics include evaluation and interpretation of experimental results, modeling and testing of tissues and cells, and biomaterial/tissue, cell interactions. BME and MSE Majors only; Juniors and Seniors.


BME 412Biomedical Signal ProcessingUNITS: 3 - Offered in Spring Only
Prerequisite: BME 311, ST 370
Fundamentals of continuous- and discrete-time signal processing as applied to problems in biomedical instrumentation. Properties of biomedical signals and instruments. Descriptions of random noise and signal processes. Interactions between randombiomedical signals and systems. Wiener filtering. Sampling theory. Discrete-time signal analysis. Applications of Z-transform and discrete Fourier transform. Digital filter design methods for biomedical instruments. BME or MS or PHD; credit not allowed for both BME 412 and BME 512.


BME 422Fundamentals of Biomedical InstrumentationUNITS: 3 - Offered in Spring Only
Prerequisite: BME 210 or BME 312
Fundamentals of biomedical instrument design and implementation. Sensing mechanisms, sensor microfabrication methods, sensor interfacing circuits, analog-to-digital conversion, biosignal capture and storage, embedded microprocessors, data compression methods, system integration and prototyping. Laboratory exercises using LabVIEW and MATLAB, supplement the topics presented in class lectures. Students build a sensor using cleanroom facilities in the BME department as part of a semester-long design project.


BME 425BioelectricityUNITS: 3 - Offered in Spring Only
Prerequisite: BME 302 or (ZO 421 and a course in electrical circuits)
Quantitative analysis of excitable membranes and their signals, including plasma membrane characteristics, origin of electrical membrane potentials, action potentials, voltage clamp experiments, the Hodgkin-Huxley equations, propagation, subthresholdstimuli, extracellular fields, membrane biophysics, and electrophysiology of the heart. Design and development of an electrocardiogram analysis system.


BME 441BiomechanicsUNITS: 3 - Offered in Fall Only
Prerequisite: ZO 160 or BIO 183; BME 342; ST 370
Students study human body kinematics, force analysis of joints, and the structure and composition of biological materials. Emphasis is placed on the measurement of mechanical properties and the development and understanding of models of biological material mechanical behavior.


BME 451Biomedical Engineering Senior Design IUNITS: 3 - Offered in Fall Only
Prerequisite: BME 302, BME 352, and either ENG 331 or ENG 333, and completion of two of the suggested BME electives for their area of emphasis ; BME majors
This course encompasses the project proposal and design concepts, including: individual pre-proposals, team proposals, project planning, scheduling, needs assessment, product requirements, competitive landscape and patent review, business risks, design concepts, and phase reviews. BME majors only.


BME 452Biomedical Engineering Senior Design IIUNITS: 3 - Offered in Spring Only
Prerequisite: BME 451, BME Majors
This course is a continuation of BME 451 moving from proposal and concepts into manufacturing, prototyping, and testing. The deliverables in this course include: detailed manufacturing specifications, biomaterials review, supplier identification, product feasibility, issues tracking, manufacturing planning, bill of materials, product risks, qualification protocol, IP disclosure, process validation planning, regulatory review, design history file audit, lessons learned, and phase reviews.


BME (TE) 466Polymeric Biomaterials EngineeringUNITS: 3 - Offered in Fall Only
Prerequisite: PY 208 and (TE 200 or CH 220 or CH 221)and(MAE 206 or CE 214)
In-depth study of the engineering design of biomedical polymers and implants. Polymeric biomaterials, including polymer synthesis and structure, polymer properties as related to designing orthopedic and vascular grafts. Designing textile products as biomaterials including surface modification and characterization techniques. Bioresorbable polymers.


BME (TE) 467Mechanics of Tissues & Implants RequirementsUNITS: 3 - Offered in Spring Only
Prerequisite: (ZO 160 or BIO 183) and (MAE 314 or CE 313)
Application of engineering and biological principles to understand the structure and performance of tendons, ligaments, skin, and bone; bone mechanics; viscoelasticity of soft biological tissues; models of soft biological tissues; mechanics of skeletal muscle; and tissue-derived devices as well as interfaces between native tissues and synthetic devices.


BME 480Biomedical Microcontroller ApplicationsUNITS: 3 - Offered in Fall Only
Prerequisite: BME 422. BME Majors only
Overview of microcontroller-based systems, including applications, architecture, number systems, and languages. Students gain experience using a PIC-based microcontroller to input information from a user and output information using LEDs and LCD displays. Student will learn capabilities of the PIC through in class exercises and weekly programming assignments. Both assembly language and PIC-based C are used. Students develop a PIC-based heart rate monitor and work in pairs on a BME-related project of their choice.


BME 481Human Factors Engineering and Quality Management Systems for EngineersUNITS: 3 - Offered in Fall Only
Co-requisite: BME 451
This course is designed for biomedical engineering students who plan to work in industry. The course covers industry related topics including team work, conflict resolution, manufacturing and specifications, gap analysis, and root cause of analysis. Design topics including design of experiment, human factors, and standards and regulations relevant to the biomedical engineering profession are also covered. Lean and six sigma are taught with an option to test for a six sigma green belt if a six sigma project is completed in the following semester.


BME (BEC) 483Tissue Engineering TechnologiesUNITS: 2 - Offered in Fall Only
Prerequisite: BIT 466/566 or permission of instructor
In this half-semester laboratory module, students will gain practical experience with two key elements of tissue engineering: tissue building and angiogenesis. Using advanced culture techniques, students will construct a complex living tissue that closely resembles its natural counterpart, then assess its ability to support ingrowth of capillaries (angiogenesis). The effects of different biomaterials and angiogenic factors will be evaluated. The engineered tissue will be embedded, sectioned and stained for histological analysis.


BME 484Tissue Engineering FundamentalsUNITS: 3 - Offered in Spring Only
Prerequisite: (ZO 160 or BIO 183), CH 221, and (MAE 301 or MSE 301 or CHE 315 or TE 303)
This course covers essential concepts of organ and tissue design and engineering using living components, including cell-based systems and cells/tissues in combination with biomaterials, synthetic materials and/or devices. Topics include: In vivo tissue structure and function; Isolation and culture of primary cells and stem cells; Principles of cellular differentiation; Mass transport processes in cell culture systems; Design, production and seeding of scaffolds for 3D culture; Design of bioreactors to support high-density cell growth; State-of-the-art engineered tissue systems; Clinical translation; and Ethics.


BME 495Special Topics in Biomedical EngineeringUNITS: 1-4 - Offered in Fall Spring Summer
Offered as needed for presenting material not normally available in regular BME Department courses or for new BME courses on a trial basis.


BME 498Undergraduate Research in Biomedical EngineeringUNITS: 3 - Offered in Fall Spring Summer
Opportunity for hands-on faculty mentored research project in biomedical engineering. Course may be a stand-alone project completed in one semester/summer or serve as part of a two-semester project. Approved plan of work required with significant independent research culminating in a final paper and presentation at the NC State Undergraduate Research Symposium or other appropriate venue. Students must identify an advisor from within the BME faculty with whom to work on a regular basis. The advisor must approve the student prior to the student registering for the course. The BME Undergraduate Coordinator must approve the use of the course as a restricted elective for the BME degree. Departmental Approval Required


BME 512Biomedical Signal ProcessingUNITS: 3 - Offered in Spring Only
Prerequisite: BME 311, and ST 370 or ST 371
Fundamentals of continuous- and discrete-time signal processing as applied to problems in biomedical instrumentation. Properties of biomedical signals and instruments. Descriptions of random noise and signal processes. Interactions between randombiomedical signals and systems. Wiener filtering. Sampling theory. Discrete-time signal analysis. Applications of Z-transform and discrete Fourier transform. Digital filter design methods for biomedical instruments. BME or graduate standing only; credit is not allowed for both BME 412 and BME 512.


BME (ECE) 522Medical InstrumentationUNITS: 3 - Offered in Spring Only
Fundamentals of medical instrumentation systems, sensors, and biomedical signal processing. Example instruments for cardiovascular and respiratory assessment. Clinical laboratory measurements, theraputic and prosthetic devices, and electrical safetyrequirements. Students should have background in electronics design using operational amplifiers.


BME 525BioelectricityUNITS: 3 - Offered in Spring Only
Prerequisite: BME 302 or ZO 421 and a course in electrical circuits, Senior standing or Graduate standing
Quantitative analysis of excitable membranes and their signals, including plasma membrane characteristics, origin of electrical membrane potentials, action potentials, voltage clamp experiments, the Hodgkin-Huxley equations, propagation, subthreshold stimuli, extracellular fields, membrane biophysics, and electrophysiology of the heart. Design and development of an electrocardiogram analysis system. Credit not given for both BME 485 and BME 585


BME (ECE) 536Digital Control SystemsUNITS: 3 - Offered in Fall Only
Prerequisite: ECE 435 and Graduate Standing in Engineering
Discrete system dynamics, sampled-data systems, mathematical representations of analog/digital and digital/analog conversions, open- and -closed-loop systems, input-output relationships, state-space and stability analyses, time and frequency domain analysis with emphasis on time domain. Design and implementation of digital controllers. Design project including hardware implementation.


BME 540Nanobiotechnology Processing, Characterization, and ApplicationsUNITS: 3 - Offered in Spring Only
Prerequisite: BIO 183 and PY 212
Topics at the interface of nanoscale science and biotechnology will be discussed. Chemical, physical, and biological properties of nanostructured biomaterials, devices, and systems. Lectures and problem-based learning will be used to present development of nanobiotechnology-enhanced materials and devices.


BME 541BiomechanicsUNITS: 3 - Offered in Fall Only
Prerequisite: ZO 160 or BIO 183, BME 342, ST 370
Students study human body kinematics, force analysis of joints, and the structure and composition of biological materials. Emphasis is placed on the measurement of mechanical properties and the development and understanding of models of biological material. Credit is not allowed for both BME 441 and BME 541.


BME 543Cardiovascular BiomechanicsUNITS: 3
Engineering principles are applied to the cardiovascular system. Anatomy of cardiovascular system; form and function of blood and blood vessels. Electric analogs; continuum mechanics with derivation of equations of motion; and constitutive models of soft tissue mechanics, with attention to normal, diseased, and adaptive processes. Programming project required.


BME 550Medical Imaging: Ultrasonic, Optical, and Magnetic Resonance SystemsUNITS: 3 - Offered in Fall Only, Offered Alternate Odd Years
Prerequisite: BME 412, ST 370 or ST 371, and PY 208
Physical and mathematical foundations of ultrasonic, optical, and magnetic resonance imaging systems in application to medical diagnostics. Each imaging modality is examined on a case-by-case basis, highlighting the following critical system characteristics: (1) underlying physics of the imaging system, including the physical mechanisms of data generation and acquisition; (2) image creation, and (3) basic processing methods of high relevance, such as noise reduction.


BME 551Medical Device DesignUNITS: 3 - Offered in Fall Only
Student multidisciplinary teams work with local medical professionals to define specific medical device concepts for implementation. Medical specialty immersion with clinical departments at local medical centers; design input based on stakeholder-needs assessment' market analysis and intellectual property review; new medical devices with broad markets; design output and device specification; product feasibility and risk assessment; design for medical device manufacturing.


BME 552Medical Device Design IIUNITS: 3
Student groups build and test prototypes of devices designed in the first course of this series. Good manufacturing practices; process validation; FDA quality system regulations; design verification and validation; regulatory approval planning; andintellectual property protection. Students will work with local patent attorneys and/or agents to draft a patent application. The final prototypes will be evaluated by clinicians for potential use with patients.


BME 560Medical Imaging: X-ray, CT, and Nuclear Medicine SystemsUNITS: 3
Prerequisite: BME 311, ST 370 or ST 371, and PY 208
Overview of medical imaging systems using ionizing radiation. Interaction of radiation with matter. Radiation production and detection. Radiography systems and applications. Tomography. PET and SPECT systems and applications.


BME (TE) 566Polymeric Biomaterials EngineeringUNITS: 3 - Offered in Fall Only
Prerequisite: PY 208 and (TE 200 or CH 220 or CH 221)and(MAE 206 or CE 214)
In-depth study of the engineering design of biomedical polymers and implants. Polymeric biomaterials, including polymer synthesis and structure, polymer properties as related to designing orthopedic and vascular grafts. Designing textile products as biomaterials including surface modification and characterization techniques. Bioresorbable polymers. Credit for TE 466 and TE 566 is not allowed.


BME (BEC) 583Tissue Engineering TechnologiesUNITS: 2 - Offered in Fall Only
Prerequisite: BIT 466/566 or permission of instructor
In this half-semester laboratory module, students will gain practical experience with two key elements of tissue engineering: the construction of a complex living tissue that closely resembles its natural counterpart, and the assessment of the angiogenic potential of he engineered tissue. The effects of different biomaterials and angiogenic factors will be evaluated.


BME 584Tissue Engineering FundamentalsUNITS: 3 - Offered in Spring Only
Prerequisite: BIO 183 and CH 221 and (MAE 301 or MSE 301 or CHE 315 or TE 303)
Essential concepts of organ and tissue design and engineering using living components, including cell-based systems and cells/tissues in combination with biomaterials, synthetic materials and/or devices. In vivo tissue structure and function; isolation and culture of primary cells and stem cells; principles of cellular differentiation; mass transport processes in cell culture systems; design, production and seeding of scaffolds for 3D culture; design of bioreactors to support high-density cell growth; state-of-the-art engineered and tissue systems; clinical translation; and ethics.


BME 590Special Topics in Biomedical EngineeringUNITS: 1-4 - Offered in Fall Spring Summer
Prerequisite: Senior or Graduate standing in Engineering or physical or biological sciences or textiles
A study of topics in the special fields under the direction of the graduate faculty.


BME 620Special Problems in Biomedical EngineeringUNITS: 1-4 - Offered in Fall Spring Summer
Prerequisite: Graduate standing in BME
Selection of a subject by each student on which to do research and write a technical report on the results. Subject may pertain to the student's particular interest in any area of study in biomedical engineering.


BME 650Internship in Biomedical EngineeringUNITS: 1 - Offered in Summer
Prerequisite: Graduate standing in BME
Students obtain professional experience through advanced engineering work in industrial and commercial settings under joint supervision of a member of the graduate faculty and an outside professional.


BME 685Master's Supervised TeachingUNITS: 1-3 - Offered in Fall Spring Summer
Prerequisite: Master's student
Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.


BME 693Master's Supervised ResearchUNITS: 1-9 - Offered in Fall Spring Summer
Prerequisite: Master's student
Instruction in research and research under the mentorship of a member of the Graduate Faculty.


BME 695Master's Thesis ResearchUNITS: 1-9 - Offered in Fall Spring Summer
Prerequisite: Master's student
Thesis research.


BME 696Summer Thesis ResearchUNITS: 1 - Offered in Summer
Prerequisite: Master's student
For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.


BME 699Master's Thesis PreparationUNITS: 1-9 - Offered in Fall and Spring
Prerequisite: Master's student
For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their thesis.


BME 790Advanced Special Topics in Biomedical EngineeringUNITS: 1-3 - Offered in Fall Spring Summer
Prerequisite: Graduate standing in engineering, physical, or biological sciences or textiles
A study of topics in advanced or emerging special areas under the direction of the graduate faculty. Experimental doctoral level courses.


BME 802Advanced Seminar in Biomedical EngineeringUNITS: 1 - Offered in Fall and Spring
Prerequisite: Doctoral student in BME or other engineering, physical science, or biological science majors, or textiles
Elaboration of advanced subject areas, techniques and methods related to professional interest through presentations of personal and published works; opportunity for students to present and critically defend ideas, concepts, and inferences; opportunity for distinguished scholars to present results of their work. Discussions to uncover analytical solutions and analogies between problems in biomedical engineering and other technologies, and to present relationship of biomedical engineering to society.


BME 885Doctoral Supervised TeachingUNITS: 1-3 - Offered in Fall Spring Summer
Prerequisite: Doctoral student
Teaching experience under the mentorship of faculty who assist the student in planning but the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment.


BME 890Doctoral Preliminary ExaminationUNITS: 1-9 - Offered in Summer
Prerequisite: Doctoral student
For students who are preparing for and taking written and/or oral preliminary exams.


BME 893Doctoral Supervised ResearchUNITS: 1-9 - Offered in Fall Spring Summer
Prerequisite: Doctoral student
Instruction in research and research under the mentorship of a member of the Graduate Faculty.


BME 895Doctoral Dissertation ResearchUNITS: 1-9 - Offered in Fall Spring Summer
Prerequisite: Doctoral student
Dissertation research.


BME 896Summer Dissertation ResearchUNITS: 1 - Offered in Summer
Prerequisite: Doctoral student
For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research.


BME 899Doctoral Dissertation PreparationUNITS: 1-9 - Offered in Fall Spring Summer
Prerequisite: Doctoral student
For students who have completed all credit hour, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations.