| BEC (MB) 180 | Introduction to Applied Bioprocessing | 3(1-4-0) SUM1,SUM2 |
| Preq: Applicants should have completed the high school courses in chemistry and biology. Departmental approval required for current NCSU students. |
| Curricular bridge between high school and college for high school and transitional students. Fundamental cell biology concepts pertaining to biomanufacturing. Students gain an understanding of the basic principles of microbiology, culture preparation, physiology, and genetics of microbial cell cultures. Team-based decisions, collaborations and consideration of multiple perspectives are emphasized. Practical experience in laboratory and culture techniques used in biomanufacturing. Transportation will be provided for field trips. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS), as well as other pre-college, transitional and early-college programs. Suitable for students with less than 30 credit hours. |
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| BEC 220 | Introduction to Drug Development and Careers in Biomanufacturing | 1(1-0-0) F,S |
| Preq: BIO 183 or ZO 160 |
| Coreq: CH 221 |
| Introduction to discovery and development of biopharmaceuticals, industrial enzymes, food ingredients and biologics. Discussion of majors that prepare students for positions in the biotechnology industry. Lectures from staff and from professionalsin the biotechnology industry focus on drug development, biopharmaceutical process development, design of biomanufacturing facilities, overview of methods used for manufacturing biopharmaceuticals, drug and enzyme purification, formulation, as well as careers in FDA compliance documentation related to manufacturing products using microbial biotechnology. |
| Course Offerings: fall sprg | |
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| BEC (MB) 320 | Fundamentals of Microbial Cell Culture | 2(1.5-00.50-0) F,S |
| Preq: BIO 181 or BIO 183 or ZO 160 |
| This is a half-semester course. This introductory module addresses fundamental cell biology concepts and enables students to gain an understanding of the basic principles of microbiology, culture preparation, physiology and genetics of microbial cell cultures. The lab portion of the course provides students with practical experience in basic laboratory and culture techniques. Students who have completed MB 352 may not take this course for credit. |
| Course Offerings: fall sprg | |
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| BEC 330 | Principles and Applications of Bioseparations | 2(1.5-00.50-0) F,S |
| Preq: CH 223 |
| Objectives, strategies, and approaches for recovery and purification of biomolecules, especially recombinant proteins. Description of common purification equipment, processes and materials used for cell lysis, precipitation, flocculation, membrane filtration, column chromatography, and centrifugation. Laboratories provide students with exposure to various techniques and the parameters that control protein isolation and purification of a recombinant protein. This is a half-semester course. Students who have completed BIT(CHE) 464 may not complete this course for credit. |
| Course Offerings: fall sprg | |
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| BEC (MB) 420 | Fundamentals of Microbial Cell Biotransformations | 2(1.5-00.50-0) F,S |
| Preq: BEC(MB) 320 or MB 352 |
| This is a half-semester course. Basic microbial cell culture theory and practice: cell physiology, mass balances, and metabolic control as seen in a dynamic bioreactor process to be scalable, consistent, and robust. The lab portion of the course provides students with hands-on experience in culture techniques using bioreactors. Students who have completed BIT (CHE) 463 may not take BEC (MB) 420 for credit. |
| Course Offerings: fall sprg | |
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| BEC 436 | Introduction to Downstream Process Development | 2(1.5-00.50-0) F,S |
| Preq: BEC 330 |
| Objectives, strategies, and approaches for recovery and purification of biomolecules, especially recombinant proteins. Laboratories in the intermediate-scale pilot plant provide students with exposure to various unit operations and the parameters that control protein isolation and purification of a recombinant protein produced by an E. coli. This is a half-semester course. |
| Course Offerings: fall sprg | |
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| BEC 440 | Expression Systems in Biomanufacturing | 3(1-5-0) F |
| Preq: BEC(MB) 320 or MB 351/352 |
| Introduction to various expression systems, their advantages and disadvantages. Basic techniques in DNA cloning, cell transformation and optimization of protein expression. Selection, archiving and characterization of production line. Media development and parameters affecting expression and yield. The lab portion of the course provides students with practical experience in DNA cloning and protein expression techniques in diverse expression systems. |
| Course Offerings: fall | |
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| BEC 480 | cGMP Fermentation Operations | 2(1.5-00.50-0) F |
| Preq: BBS(BEC) 426 |
| Application of microbial fermentation techniques at production scale and evaluation of the inherent issues resulting from the integration of microbial fermentation unit operations, scale-up/production, and current Good Manufacturing (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in media preparation, bioreactor operation, process utilities, and manufacturing quality systems that simulate microbial cell growth and product expression in a commercial cGMP facility. This is a half-semester course. |
| Course Offerings: fall sprg | |
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| BEC 485 | cGMP Downstream Operations | 2(1.5-00.50-0) F,S |
| Preq: BEC 436 |
| Application of downstream bioprocessing techniques at production scale and evaluation of the inherent issues resulting from the integration of recovery and purification unit operations, scale-up/production issues, and current Good Manufacturing Practice (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in cell removal, cell disruption, purification, and manufacturing quality systems that simulate downstream bioprocessing in a commercial cGMP facility. This is a half-semester course. |
| Course Offerings: fall sprg | |
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| BEC 495 | Special Topics in Biomanufacturing | 1-4 |
| Offered as needed to present materials not normally available in regular course offerings or for offering of new courses on a trial basis. Departmental approval required. |
| Course Offerings: fall sum2 sprg | |
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| BEC 497 | Biomanufacturing Research Projects | 1-3 F,S,SUM1,SUM2 |
| Introduction to biomanufacturing research through experimental, theoretical, and literature studies. Oral and written presentation of reports. Departmental approval required. |
| Course Offerings: fall sprg | |
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| BEC 595 | Special Topics in Biomanufacturing | 1-4 F, S |
| Preq: Graduate or advanced undergraduate standing in engineering, biological science, or physical science. |
| Offered to present graduate course content not available in existing courses or for offering of new graduate courses on a trial basis. Departmental approval required. |
| Course Offerings: fall sprg | |