| BEC (MB) 180 | Introduction to Applied Bioprocessing | UNITS: 3 |
| Curricular bridge between high school and college for high school and transitional students. Fundamental cell biology concepts pertaining to biomanufacturing. Students gain an understanding of the basic principles of microbiology, culture preparation, physiology, and genetics of microbial cell cultures. Team-based decisions, collaborations and consideration of multiple perspectives are emphasized. Practical experience in laboratory and culture techniques used in biomanufacturing. Transportation will be provided for field trips. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS), as well as other pre-college, transitional and early-college programs. Suitable for students with less than 30 credit hours. |
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| BEC 220 | Introduction to Drug Development and Careers in Biomanufacturing | UNITS: 1 - Offered in Fall and Spring |
| Prerequisite: BIO 183 or ZO 160, Corequisite: CH 221 |
| Introduction to discovery and development of biopharmaceuticals, industrial enzymes, food ingredients and biologics. Discussion of majors that prepare students for positions in the biotechnology industry. Lectures from staff and from professionalsin the biotechnology industry focus on drug development, biopharmaceutical process development, design of biomanufacturing facilities, overview of methods used for manufacturing biopharmaceuticals, drug and enzyme purification, formulation, as well as careers in FDA compliance documentation related to manufacturing products using microbial biotechnology. |
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| BEC (MB) 320 | Fundamentals of Microbial Cell Culture | UNITS: 2 - Offered in Fall Spring Summer |
| Prerequisite: BIO 183 |
| This is a half-semester course. This introductory module addresses fundamental cell biology concepts and enables students to gain an understanding of the basic principles of microbiology, culture preparation, physiology and genetics of microbial cell cultures. The lab portion of the course provides students with practical experience in basic laboratory and culture techniques. Students who have completed MB 352 may not take this course for credit. |
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| BEC 330 | Principles and Applications of Bioseparations | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: CH 223 |
| Objectives, strategies, and approaches for recovery and purification of biomolecules, especially recombinant proteins. Description of common purification equipment, processes and materials used for cell lysis, precipitation, flocculation, membrane filtration, column chromatography, and centrifugation. Laboratories provide students with exposure to various techniques and the parameters that control protein isolation and purification of a recombinant protein. This is a half-semester course. Students who have completed BIT(CHE) 464 may not complete this course for credit. |
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| BEC (MB) 420 | Fundamentals of Microbial Cell Biotransformations | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: BEC(MB) 320 or MB 352 |
| This is a half-semester course. Basic microbial cell culture theory and practice: cell physiology, mass balances, and metabolic control as seen in a dynamic bioreactor process to be scalable, consistent, and robust. The lab portion of the course provides students with hands-on experience in culture techniques using bioreactors. Students who have completed BIT (CHE) 463 may not take BEC (MB) 420 for credit. |
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| BEC 436 | Introduction to Downstream Process Development | UNITS: 2 |
| Prerequisite: BEC 330 or graduate standing |
| Objectives, strategies, and approaches for recovery and purification of biomolecules, especially recombinant proteins. Laboratories in the intermediate-scale pilot plant provide students with exposure to various unit operations and the parameters that control protein isolation and purification of a recombinant protein produced by an E. coli. This is a half-semester course. Students who have completed BEC 436 may not take BEC 536 for credit. |
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| BEC 440 | Expression Systems in Biomanufacturing | UNITS: 3 |
| Prerequisite: BEC(MB) 320 or MB 351/352 |
| Introduction to various expression systems, their advantages and disadvantages. Basic techniques in DNA cloning, cell transformation and optimization of protein expression. Selection, archiving and characterization of production line. Media development and parameters affecting expression and yield. The lab portion of the course provides students with practical experience in DNA cloning and protein expression techniques in diverse expression systems. |
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| BEC 442 | Insect Cells Protein Expression | UNITS: 2 - Offered in Spring Only |
| Prerequisite: BEC(MB) 320 or BIT410/510 |
| Introduction to the insect cells expression system, and its advantages and disadvantages. Introduction to expression of recombinant proteins with baculovirus. Outline of antibody and antibody fragments as well as other complex proteins. Basic techniques used for growth and maintenance of insect cell cultures. The lab portion of the course provides students with practical experience in protein expression techniques in the insect cells expression system. This is a half-semester course. Students who have completed BEC 442 may not take BEC 542 for credit. |
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| BEC 462 | Bio-Nanotechnology Laboratory | UNITS: 2 - Offered in Fall Only |
| Prerequisites: MA 241, PY 208, BCH 451 and CH 223 |
| Concepts of nanotechnology are applied in the synthesis, characterization, recognition and application of biomaterials on the nanoscale. Emphasis will be given to hands-on experience with nanostructured biomaterials; students will also be familiarized with the potential impact of these materials on different aspects of society and potential hazards associated with their preparation and application. |
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| BEC (CHE) 463 | Fermentation of Recombinant Microorganisms | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: BEC 320 or BIT 410 or BCH 452 or MB 352 |
| Introduction to fermentation and protein chemistry. Theory behind laboratory techniques and overview of industrial scale expression systems. Laboratory sessions involve use of microbial expression vectors, fermentation systems, and large-scale purification of recombinant protein. Half semester course, first part. |
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| BEC 475 | Global Regulatory Affairs for Medical Products | UNITS: 3 - Offered in Spring Only |
| Prerequisite: Senior standing |
| This lecture-based course introduces students to the quality systems used to meet the regulatory requirements for developing, testing, manufacturing, and selling medical products in the global marketplace. It provides a general background for those going into the medical products field, but is especially useful to students preparing for a career in the Regulatory Affairs or Quality Assurance Department within a pharmaceutical, biomanufacturing, or medical device company. |
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| BEC 480 | cGMP Fermentation Operations | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: BBS(BEC) 426 |
| Application of microbial fermentation techniques at production scale and evaluation of the inherent issues resulting from the integration of microbial fermentation unit operations, scale-up/production, and current Good Manufacturing (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in media preparation, bioreactor operation, process utilities, and manufacturing quality systems that simulate microbial cell growth and product expression in a commercial cGMP facility. This is a half-semester course. Students who have completed BEC 480 may not take BEC 580 for credit. |
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| BEC (BME) 483 | Tissue Engineering Technologies | UNITS: 2 - Offered in Fall Only |
| Prerequisite: BIT 466 or permission of instructor |
| In this half-semester laboratory module, students will gain practical experience with two key elements of tissue engineering: tissue building and angiogenesis. Using advanced culture techniques, students will construct a complex living tissue that closely resembles its natural counterpart, then assess its ability to support ingrowth of capillaries (angiogenesis). The effects of different biomaterials and angiogenic factors will be evaluated. The engineered tissue will be embedded, sectioned and stained for histological analysis. |
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| BEC 485 | cGMP Downstream Operations | UNITS: 2 |
| Prerequisite: BEC 436 |
| Application of downstream bioprocessing techniques at production scale and evaluation of the inherent issues resulting from the integration of recovery and purification unit operations, scale-up/production issues, and current Good Manufacturing Practice (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in cell removal, cell disruption, purification, and manufacturing quality systems that simulate downstream bioprocessing in a commercial cGMP facility. This is a half-semester course. Students who have completed BEC 485 may not take BEC 585 for credit. |
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| BEC 495 | Special Topics in Biomanufacturing | UNITS: 1-4 |
| Offered as needed to present materials not normally available in regular course offerings or for offering of new courses on a trial basis. Departmental approval required. |
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| BEC 497 | Biomanufacturing Research Projects | UNITS: 1-3 - No Course Evaluation |
| Introduction to biomanufacturing research through experimental, theoretical, and literature studies. Oral and written presentation of reports. Departmental approval required. |
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| BEC 532 | Biological Processing Science | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: BCH 451 or graduate standing |
| Fundamental scientific principles underlying the recovery, purification and formulation of biologics (biotherapuetics), especially proteins, are examined. Emphasis is placed on delineating the key chemical and physical properties of biomolecules that impact processing and formulation development. Laboratories in the analytical and small-scale purification facility provide students with 'hands-on' exposure to key scientific principles and small scale unit operations. This is a half-semester course. |
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| BEC 536 | Introduction to Downstream Process Development | UNITS: 2 |
| Objectives, strategies, and approaches for recovery and purification of biomolecules, especially recombinant proteins. Laboratories in the intermediate-scale pilot plant provide students with exposure to various unit operations and the parameters that control protein isolation and purification of a recombinant protein produced by an E. coli. This is a half-semester course. Students who have completed BEC 436 may not take BEC 536 for credit. |
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| BEC 542 | Insect Cells Protein Expression | UNITS: 2 - Offered in Spring Only |
| Prerequisite: BEC(MB) 320 or BIT410/510 |
| Introduction to the insect cells expression system, and its advantages and disadvantages. Introduction to expression of recombinant proteins with baculovirus. Outline of antibody and antibody fragments as well as other complex proteins. Basic techniques used for growth and maintenance of insect cell cultures. The lab portion of the course provides students with practical experience in protein expression techniques in the insect cells expression system. This is a half-semester course. Students who have completed BEC 442 may not take BEC 542 for credit. |
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| BEC 562 | Bio-Nanotechnology Laboratory | UNITS: 2 - Offered in Fall Only |
| Prerequisites: MA 241, PY 208, BCH 451 and CH 223 |
| Concepts of nanotechnology are applied in the synthesis, characterization, recognition and application of biomaterials on the nanoscale. Emphasis will be given to hands-on experience with nanostructured biomaterials; students will also be familiarized with the potential impact of these materials on different aspects of society and potential hazards associated with their preparation and application. |
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| BEC 580 | cGMP Fermentation Operations | UNITS: 2 - Offered in Fall and Spring |
| Prerequisite: BBS(BEC) 426 |
| Application of microbial fermentation techniques at production scale and evaluation of the inherent issues resulting from the integration of microbial fermentation unit operations, scale-up/production, and current Good Manufacturing (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in media preparation, bioreactor operation, process utilities, and manufacturing quality systems that simulate microbial cell growth and product expression in a commercial cGMP facility. This is a half-semester course. Students who have completed BEC 480 may not take BEC 580 for credit. |
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| BEC 585 | cGMP Downstream Operations | UNITS: 2 |
| Prerequisite: BEC 436 |
| Application of downstream bioprocessing techniques at production scale and evaluation of the inherent issues resulting from the integration of recovery and purification unit operations, scale-up/production issues, and current Good Manufacturing Practice (cGMP) compliance. Lectures prepare students for pilot-scale laboratory experiences in cell removal, cell disruption, purification, and manufacturing quality systems that simulate downstream bioprocessing in a commercial cGMP facility. This is a half-semester course. Students who have completed BEC 485 may not take BEC 585 for credit. |
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| BEC 595 | Special Topics in Biomanufacturing | UNITS: 1-4 |
| Offered to present graduate course content not available in existing courses or for offering of new graduate courses on a trial basis. Departmental approval required. |
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| BEC 669 | Biomanufacturing Research Projects | UNITS: 1-4 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Graduate standing in engineering, biological science or physical science |
| Introduction to biomanufacturing research through experimental, theoretical and literature studies under the mentorship of a member of the graduate faculty. Oral and written presentation of reports. Deptartmental approval required. |
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