| BCH (MB) 101 | Introduction to Microbiology and Biochemistry Laboratory Practices | UNITS: 3 - Offered in Spring Only |
| Curricular bridge between high school and college for high school and transitional students. A "hands on" introduction to fundamentals in Microbiology and Biochemistry. Bacterial isolation, identification and growth using aseptic technique, microscopy, and metabolic analysis. Experiments with DNA isolation and analysis, protein isolation, and purification, and enzyme kinetics. Lectures and readings on background, theory and applications of these techniques. Field trips to university and industry research laboratories. This course is part of the Summer College in Biotechnology and Life Sciences (SCIBLS) as well as other pre-college, transitional and early-college programs and is offered as 4 week intensive course. Applicants should have completed high school courses in biology and chemistry. Students must have completed no more than 30 credit hours. Departmental approval is required for current NCSU students. |
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| BCH 220 | Role of Biotechnology in Society | UNITS: 3 - Offered in Summer |
| Prerequisite: BIO 181, CH 101 |
| Biotechnology and Societing is an introductory science course that takes a semi-technical look at the emerging role of biotechnology in human society. Expectations are that students will gain an appreciation for biotechnology, the ability to understand how biotechnology works. Offered only in Poland through Study Abroad (4-week course). Departmental approval required. |
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| BCH 451 | Principles of Biochemistry | UNITS: 4 - Offered in Fall Spring Summer |
| Prerequisite: CH 223 |
| Introduction to the fundamental principles of biochemistry. Emphasis on biochemical structures, properties, functions and interactions, including enzyme kinetics and central pathways of metabolism. |
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| BCH 452 | Introductory Biochemistry Laboratory | UNITS: 2 - Offered in Fall and Spring |
| Corequisite: BCH 451 |
| Laboratory experience to complement BCH 451. Basic skills in the use of volumetric equipment, spectrophotometers, chromatography, and electrophoresis. Manipulation and assay of small quantities of biological materials, and analysis of laboratory data. |
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| BCH 453 | Biochemistry of Gene Expression | UNITS: 3 - Offered in Fall and Spring |
| Prerequisite: BCH 451, Corequisite: GN 411, MB 351 |
| Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit is not allowed for both BCH 453 and BCH 553. |
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| BCH 454 | Advanced Biochemistry Laboratory | UNITS: 4 - Offered in Fall Only |
| Prerequisite: BCH 452, Corequisite: BCH 453 |
| Techniques in molecular biology and protein purification. Cloning and expression of a eukaryotic gene in bacteria followed by purification of the eukaryotic gene product. Microanalysis of DNA, RNA and protein. |
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| BCH 455 | Proteins and Molecular Mechanisms | UNITS: 3 - Offered in Spring Only |
| Prerequisite: BCH 451, BCH 453/553 |
| Principles of protein structure and function, protein folding, enzymology, ligand binding, protein transport, and metabolic pathways. |
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| BCH 492 | External Learning Experience | UNITS: 1-6 - No Course Evaluation, Offered in Fall and Spring |
| Prerequisite: Sophomore standing |
| A learning experience in agriculture and life sciences within an academic framework that utilizes facilities and resources which are external to the campus. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and academic dean prior to the experience. |
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| BCH 493 | Special Problems in Biochemistry | UNITS: 1-6 - No Course Evaluation, Offered in Fall and Spring |
| Prerequisite: Sophomore standing |
| A learning experience in agriculture and life sciences within an academic framework that utilizes campus facilities and resources. Contact and arrangements with prospective employers must be initiated by student and approved by a faculty adviser, the prospective employer, the departmental teaching coordinator and the academic dean prior to the experience. |
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| BCH 495 | Special Topics in Biochemistry | UNITS: 1-5 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Junior standing |
| Offered as needed to present materials not normally available in regular BCH departmental courses or for new BCH courses on a trial basis. |
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| BCH 552 | Experimental Biochemistry | UNITS: 3 - Offered in Fall Only |
| Prerequisite: BCH 452;BCH 453 |
| An advanced laboratory to give students practical experiences in purification and quantitative characterization of enzymes and nucleic acids. Studies with carbohydrates and membrane lipids. Credit may be applied toward biotechnology minor. |
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| BCH 553 | Biochemistry of Gene Expression | UNITS: 3 - Offered in Fall and Spring |
| Prerequisite: BCH 451, Corequisite: GN 411, MB 351 |
| Structure and function of nucleic acids and proteins. Synthesis of DNA, RNA, and proteins. Gene expression and Regulation. Methodologies of recombinant DNA research. Credit in both BCH 453 and BCH 553 is not allowed. |
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| BCH 555 | Proteins and Molecular Mechanisms | UNITS: 3 - Offered in Spring Only |
| Prerequisite: BCH 451, BCH 453/553 |
| Principlies of protein structure and function, protein folding, enzymology, ligand binding, protein transport, and metabolic pathways. |
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| BCH (ANS) 571 | Regulation of Metabolism | UNITS: 3 - Offered Alternate Odd Years, Offered in Fall Only |
| Prerequisite: BCH 451, GN 411, a course in physiology, cell biology |
| Study of hormonal, enzymatic and molecular-genetic regulation of carbohydrate and lipid metabolism; emphasis on mammalian species. |
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| BCH 590 | Special Topics in Biochemistry | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: BCH 451 |
| The study of topics of special interest by small groups of students instructed by members of the faculty. |
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| BCH 601 | Macromolecular Structure | UNITS: 1 - Offered in Fall Only |
| Prerequisite: BCH 453 or BCH 553; a course in physical chemistry highly recommended |
| Introduction to the current understanding and methods used for the study of structures, thermodynamics and conformational dynamics of proteins, nucleic acids and membranes. |
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| BCH 610 | Special Topics | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: BCH 451 |
| The study of topics of special interest by small groups of students instructed by members of the faculty. |
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| BCH 615 | Special Topics In Biochemistry | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: Graduate standing in BCH |
| Critical study of special problems and selected topics of current interest in biochemistry and related fields. |
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| BCH 660 | Free Radicals In Toxicology | UNITS: 1 |
| Prerequisite: BCH 451 and TOX 710 |
| Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms |
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| BCH 670 | Laboratory Rotations | UNITS: 1 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: BCH 451 |
| Performance of highly directed research by biochemistry students in one or more laboratories of student's choice prior to beginning thesis research. Each laboratory experience lasts 5 weeks and given 1 hr. of credit. No more than 4 credits earned inBCH 692. |
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| BCH 685 | Master's Supervised Teaching | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment. |
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| BCH 688 | Non-Thesis Masters Continuous Registration - Half Time Registration | UNITS: 1 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain half-time continuous registration to complete incomplete grades, projects, final master's exam, etc. |
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| BCH 689 | Non-Thesis Master Continuous Registration - Full Time Registration | UNITS: 3 - Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non-thesis master's programs who have completed all credit hour requirements for their degree but need to maintain full-time continuous registration to complete incomplete grades, projects, final master's exam, etc. Students may register for this course a maximum of one semester. |
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| BCH 690 | Master's Examination | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students in non-thesis master's programs who have completed all other requirement of the degree except preparing for and taking the final master's exam. |
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| BCH 693 | Master's Supervised Research | UNITS: 1-9 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| Instruction in research and research under the mentorship of a member of the Graduate Faculty. |
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| BCH 695 | Master's Thesis Research | UNITS: 1-9 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| Thesis research |
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| BCH 696 | Summer Thesis Research | UNITS: 1 - Offered in Summer |
| Prerequisite: Master's student |
| For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research. |
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| BCH 699 | Master's Thesis Preparation | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Master's student |
| For students who have completed all credit hour requirements and full-time enrollment for the master's degree and are writing and defending their thesis. |
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| BCH 701 | Macromolecular Structure | UNITS: 3 - Offered in Fall Only |
| Prerequisite: BCH 453 or BCH 553; a course in physical chemistry highly recommended |
| Introduction to the current understanding and methods used for the study of structures, thermodynamics and conformational dynamics of proteins, nucleic acids and membranes. |
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| BCH 703 | Macromolecular Synthesis and Regulation | UNITS: 3 - Offered in Fall Only |
| Prerequisite: BCH 453 or BCH 553 |
| Biochemistry of DNA replication, transcription, RNA processing and translation. Development of key concepts, techniques and applications relating to mechanisms and regulation of these processes by analysis of primary literature. |
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| BCH 705 | Molecular Biology Of the Cell | UNITS: 3 - Offered in Spring Only |
| Prerequisite: BCH 701 or BCH 703 |
| Regulation of cellular processes, membrane structure and function, signal transduction, protein trafficking/sorting, secretion, photosynthesis and nitrogen fixation. |
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| BCH 751 | Biophysical Chemistry | UNITS: 3 - Offered Alternate Years, Offered in Fall Only |
| Prerequisite: BCH 451; one sem. of physical chemistry |
| Fundamental and practical aspects of biological macromolecular structure, thermodynamics, hydrodynamics, kinetics and spectroscopy with emphasis on mechanisms in functionally important structural transformations. |
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| BCH (GN) 761 | Advanced Molecular Biology Of the Cell | UNITS: 3 - Offered Alternate Years, Offered in Spring Only |
| Prerequisite: BCH 703 and 705 |
| An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions. |
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| BCH 763 | Biochemistry Of Hormone Action | UNITS: 3 - Offered Alternate Years, Offered in Spring Only |
| Prerequisite: BCH 705 or GN 757 |
| Study of well-defined models of steroid and protein hormone action via lectures, assigned readings and discussions. Students add breadth to the course and depth to their own understanding by searching the literature and writing or lecturing about a particular hormone of their own choosing. |
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| BCH (GN) 768 | Nucleic Acids: Structure and Function | UNITS: 3 - Offered Alternate Years, Offered in Spring Only |
| Prerequisite: BCH 701 and 703 |
| An advanced treatment involving integrated approaches to biological problems at the molecular level, encompassing biochemistry, cell biology and molecular genetics. Broad, multidisciplinary approaches to solving research problems in biology and thecritical study of primary scientific literature, the development of a research proposal, oral presentations and class discussions. |
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| BCH 801 | Seminar In Biochemistry | UNITS: 1 - No Course Evaluation, Offered in Fall and Spring |
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| BCH 810 | Special Topics | UNITS: 1-3 - Offered in Fall Spring Summer |
| Prerequisite: BCH 451 |
| The study of topics of special interest by small groups of students instructed by members of the faculty. |
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| BCH 815 | Advanced Special Topics | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Graduate standing in BCH |
| Critical study of special problems and selected topics of current interest in biochemistry and related fields. |
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| BCH 860 | Free Radicals in Toxicology | UNITS: 1 |
| Prerequisite: BCH 451 and TOX 710 |
| Introduction to the field of free radicals and their role in toxicology and health; chemical and physical properties of partially reduced oxygen intermediates and the natural biological defense mechanisms. |
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| BCH 870 | Laboratory Rotations | UNITS: 1 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: BCH 451 |
| Performance of highly directed research by biochemistry students in one or more laboratories of student's choice prior to beginning thesis research. Each laboratory experience lasts 5 weeks and given 1 hr. of credit. No more than 4 credits earned inBCH 692. |
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| BCH 885 | Doctoral Supervised Teaching | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| Teaching experience under the mentorship of faculty who assist the student in planning for the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment. |
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| BCH 890 | Doctoral Preliminary Examination | UNITS: 1-9 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| For students who are preparing for and taking written and/or oral preliminary exams. |
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| BCH 893 | Doctoral Supervised Research | UNITS: 1-9 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| Instruction in research and research under the mentorship of a member of the Graduate Faculty. |
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| BCH 895 | Doctoral Dissertation Research | UNITS: 1-9 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| Dissertation research |
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| BCH 896 | Summer Dissertation Research | UNITS: 1 - Offered in Summer |
| Prerequisite: Doctoral student |
| For graduate students whose programs of work specify no formal course work during a summer session and who will be devoting full time to thesis research. |
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| BCH 899 | Doctoral Dissertation Preparation | UNITS: 1-3 - No Course Evaluation, Offered in Fall Spring Summer |
| Prerequisite: Doctoral student |
| For students who have completed all credit hours, full-time enrollment, preliminary examination, and residency requirements for the doctoral degree, and are writing and defending their dissertations. |
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